Embryo cryopreservation is one of the most true and trusted methods of assisted reproductive technologies. In 1984 the first baby was born in the result of thawed embryo transfer. Most of clinics use cryopreservation of embryos left after IVF for their further transfer.
Using frozen embryos the chances for conception are reduced. However we strongly recommend our patients to cryopreserve embryos if any were left after the transfer. The cycle of cryopreservation and transfer of thawed embryos is much cheaper than a new IVF cycle. Besides, frozen embryos are kind of a guaranty for patients in case pregnancy might not occur.
Almost half of all embryos of good quality survive after freezing and thawing. Embryo cryopreservation does not increase the risk of developing congenital pathologies.
Advantages of cryopreservation
Freezing and thawing of embryos.
Embryos are frozen at any stage (pronucleus, cleavage, blastocyte) if they are of good quality. Embryos are stored by one or in groups depending on the number of embryos to transfer into the uterus.
Embryos are combined with cryoprotectant (a special substance used to protect biological tissue from freezing damage). Then embryos are placed in plastic straws for freezing using the method of flash freezing (vitrification). Embryos are stored in liquid nitrogen at 196°C.
Embryos are removed from liquid nitrogen and they thaw at room temperature. The Cryoprotectant is also removed and embryos are placed in special media.
In case embryos were frozen at cleavage or blastocyte stage, they can be thawed and transferred into the uterus at the same day. However, if they were frozen at pronucleus stage, embryos should be thawed a day before transfer, incubated for a day to assess their cleavage and transferred to the uterus at the 2-4-cell stage embryo.
How long frozen embryos can be stored? Frozen embryos can be stored for a long time, as long as you need them even for decades. When embryos are stored in liquid nitrogen at 196°C, cell metabolism does not continue.
It is very important that patients kept in contact with the clinic and be informed about their frozen embryos. At the end of each paid period, patients should inform the clinic what they would like to do with their embryos:
To do that, patients must sign an informed consent to get the embryos that are stored in the clinic. Embryos are transported in a small container with liquid nitrogen. After patients receive their embryos, they become fully responsible for them.
Not all embryos survive after freezing and thawing. In a clinic with effective program of cryopreservation, the rate of embryo survival is 75-80%. Embryos can be damaged in the result of cryopreservation but not during storage. They can be damaged during the process of freezing and thawing. For this reason, sometimes several embryos are thawed to get 2-3 embryos of good quality to transfer them to the uterus.
The clinic employs some of the best specialists in the field of reproduction, genetics and embryology in Russia. Our specialists - doctors of the highest category, PhDs, who were trained in Europe and the US.
Examination and treatment of our patients is carried out on modern high-tech German or Japanese equipment.
There is a Quality Control Department operating in our Clinic. If you have any questions or feedback on our services, please feel free to contact us using the form below. The Management will consider your inquiry and contact you shortly.
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